TGFBR3 translation

Stable Identifier
R-HSA-9839396
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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TGFBR3 translation
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Micro RNA let‑7a (Wang et al, 2019), miR‑23b‑3p and miR‑27b‑3p (Yang et al., 2019) suppresses the translation of TGFBR3 and reduce its expression. This has been confirmed using Microarray and gene expression analysis, Fluorescence immunohistochemistry (FIHC) assay, Quantitative mRNA and miRNA measurements assays in human prostate cancer cells lines having bone metastatic capabilities, C42B and PC3‑2M, and Human atrial fibroblasts (HAFs).
Literature References
PubMed ID Title Journal Year
30467960 MicroRNA let-7a regulates angiogenesis by targeting TGFBR3 mRNA

Chen, C, Wu, D, Xiang, Y, Ni, H, Zhou, H, Wang, S, Dai, K, Chen, X, Chen, Z, Li, X

J Cell Mol Med 2019
30729664 Novel role of the clustered miR-23b-3p and miR-27b-3p in enhanced expression of fibrosis-associated genes by targeting TGFBR3 in atrial fibroblasts

Yang, J, Li, H, Fang, X, Shan, Z, Pan, R, Wu, S, Guo, H, Yuan, S, Yang, Z, Zhu, J, Zheng, XL, Xiao, Z, Liang, J, Dong, W

J Cell Mol Med 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
miR-Let7-a1 RISC:TGFBR3 mRNA [cytosol] (Homo sapiens)
Active Unit
miR-Let7-a1 RISC [cytosol]
Regulator
miR-27b:TGFBR3 mRNA [cytosol] (Homo sapiens)
Active Unit
miR-27b RISC [cytosol]
Regulator
miR-23b RISC:TGFBR3 mRNA [cytosol] (Homo sapiens)
Active Unit
miR-23b RISC [cytosol]
Authored
Tiwari, K  (2023-07-25)
Created
Tiwari, K  (2023-07-05)
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