TGFBR3 PTM regulation

Stable Identifier
R-HSA-9839383
Type
Pathway
Species
Homo sapiens
ReviewStatus
3/5
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TGFBR3 PTM regulation
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This subpathway includes the post-translation modification reactions of TGFBR3 including its plasma membrane localization and extracellular regulation by MT-MMPs and Gamma-secretase (Knappenberger et al.,2017, Velasco-loyden et al.,2004, Blari et al.,2011).
Literature References
PubMed ID Title Journal Year
21167215 The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase

Wells, RG, Blair, CR, Stone, JB

Biochim Biophys Acta 2011
14672946 The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1

Arribas, J, Velasco-Loyden, G, López-Casillas, F

J Biol Chem 2004
15147205 Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Ye, X, Ghanekar, SV, Greenberg, BD, Tian, G, Scott, CW, Sobotka-Briner, C, Knappenberger, KS

Biochemistry 2004
Participants
Events
Participates
as an event of
Orthologous Events
TGFBR3 PTM regulation (Bos taurus)
TGFBR3 PTM regulation (Canis familiaris)
TGFBR3 PTM regulation (Danio rerio)
TGFBR3 PTM regulation (Gallus gallus)
TGFBR3 PTM regulation (Mus musculus)
TGFBR3 PTM regulation (Rattus norvegicus)
TGFBR3 PTM regulation (Sus scrofa)
TGFBR3 PTM regulation (Xenopus tropicalis)
Authored
Tiwari, K  (2023-07-25)
Created
Tiwari, K  (2023-07-05)
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