Reactome | FGF2:TGFBR3 binding to GIPC1

FGF2:TGFBR3 binding to GIPC1

Stable Identifier

R-HSA-9839381

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytoplasmic side of plasma membrane

ReviewStatus

3/5

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GIPC1 binding to FGF2:TGFBR3 is essential for the FGF2 medaited neuronal differentiation (Knelson et al., 2013). Site-directed mutagenesis in epicardial cells (Sanchez et al, 2011) show the important of GIPC1 and TGFBR3 in enhancing FGF2:FGFR1 signaling.

Literature References

PubMed ID	Title	Journal	Year
21871877	The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior Barnett, JV, Camenisch, TD, Craig, E, Czirok, A, Hill, CR, Austin, AF, Brown, CB, Love, JD, Soslow, JH, Sánchez, NS	Dev Biol	2011
24216509	Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma Mythreye, K, Blobe, GC, Armstrong, MB, Gaviglio, AL, Tewari, AK, Knelson, EH	J Clin Invest	2013