TGFBR3 transcription

Stable Identifier
R-HSA-9839371
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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TGFBR3 transcription
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TGFBR3 is transcriptionally regulated by SP1, MyoD and its promoter contains RAR binding element (López‑Casillas., 2003, Cook et al, 2019). Using Transient Transfection, TGF‑β Affinity Labeling and Immunoprecipitation techniques, transcriptional regulation of TGFBR3 by these transcription factors has been confirmed in the C2C12 myoblast cell line (López‑Casillas., 2003). TGFBR3 transcription is also known to be negatively regulated by TGFbeta signaling through SMADs (Hempel et al.,2008), negatively regulated by MYCN through an HDAC1-mediated mechanism (Knelson et al.,2013) and also epigenetically through HELLS (Hou et al.,2021) and KLF16 (Chen et al.,2022).
Literature References
PubMed ID Title Journal Year
31409900 Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis

Cook, LM, Frieling, JS, Nerlakanti, N, McGuire, JJ, Stewart, PA, Burger, KL, Cleveland, JL, Lynch, CC

Oncogene 2019
33280236 HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3

Hou, X, Yang, L, Wang, K, Zhou, Y, Li, Q, Kong, F, Liu, X, He, J

Cancer Med 2021
24216509 Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

Knelson, EH, Gaviglio, AL, Tewari, AK, Armstrong, MB, Mythreye, K, Blobe, GC

J Clin Invest 2013
35173481 KLF16 Downregulates the Expression of Tumor Suppressor Gene TGFBR3 to Promote Bladder Cancer Proliferation and Migration

Chen, X, Wang, P, Ou, T, Li, J

Cancer Manag Res 2022
12399463 Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta

López-Casillas, F, Riquelme, C, Perez-Kato, Y, Ponce-Castaneda, MV, Osses, N, Esparza-Lopez, J, Gonzalez-Nunez, G, Cabello-Verrugio, C, Mendoza, V, Troncoso, V, Brandan, E

J Biol Chem 2003
18299279 Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta

Hempel, N, How, T, Cooper, SJ, Green, TR, Dong, M, Copland, JA, Wood, CG, Blobe, GC

Carcinogenesis 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
KLF16 [nucleoplasm] (Homo sapiens)
Active Unit
KLF16 [nucleoplasm]
Regulator
HELLS [nucleoplasm] (Homo sapiens)
Active Unit
HELLS [nucleoplasm]
Regulator
MYCN [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1 [nucleoplasm]
Regulator
(2xp-2S-SMAD3):SMAD4:SP1:EP300 [nucleoplasm] (Homo sapiens)
Active Unit
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm]
Positively by
Regulator
SP1:TGFBR3 gene [nucleoplasm] (Homo sapiens)
Active Unit
SP1 [nucleoplasm]
Regulator
MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
Active Unit
MYOD1 [nucleoplasm]
Regulator
aTRA:TGFBR3 gene [nucleoplasm] (Homo sapiens)
Active Unit
RARA [nucleoplasm]
Authored
Tiwari, K  (2023-07-25)
Created
Tiwari, K  (2023-07-05)
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