TGFBR3(1-783) binds to TGFB1,TGFB2

Stable Identifier
R-HSA-9839368
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
3/5
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TGFBR3(1-783) binds to TGFB1,TGFB2
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Soluble fragments of TGFBR3(1-783) genearted by MMPs maintain their TGFB1/TGFB2 binding ability. It binds with TGFB1/TGBF2 and sequester TGFB ligands (TGFB1/TGBF2) away from TGFBR2 receptor leading to suppression of TGFbeta signaling (Lopez-Casillas et al., 1994).
Literature References
PubMed ID Title Journal Year
8106553 Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

Payne, HM, López-Casillas, F, Massagué, J, Andres, JL

J Cell Biol 1994
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Orthologous Events
TGFBR3(1-783) binds to TGFB1,TGFB2 (Bos taurus)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Canis familiaris)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Danio rerio)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Gallus gallus)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Mus musculus)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Rattus norvegicus)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Sus scrofa)
TGFBR3(1-783) binds to TGFB1,TGFB2 (Xenopus tropicalis)
Authored
Tiwari, K  (2023-07-25)
Created
Tiwari, K  (2023-07-05)
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