HTRA2 degrades NDUFA13 (GRIM-19)

Stable Identifier
R-HSA-9839110
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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HTRA2 degrades NDUFA13 (GRIM-19)
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HTRA2 (OMI) cleaves NDUFA13 (GRIM-19) at six sites (Kummari et al. 2021). Interaction of NDUFA13 with the N-terminus of HTRA2 allosterically activates the protease activity of HTRA2 (Kummari et al. 2021). Self-cleavage by HTRA2 releases HTRA2 into the cytosol where it activates apoptosis by binding and cleaving inhibitors of apoptosis (reviewed in Chakraborty et al. 2022). NDUFA13 acts to promote the apoptotic activity of HTRA2 (Ma et al. 2007). The effect of the cleavage of NDUFA13 on apoptosis is unclear.
Literature References
PubMed ID Title Journal Year
33650635 Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2

Mudrale, SP, Kummari, R, Dutta, S, Bose, K, Patil, S

Biochem J 2021
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Catalyst Activity

serine-type peptidase activity of HTRA2:NDUFA13 [mitochondrial inner membrane]

Physical Entity
HTRA2:NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
Activity
serine-type peptidase activity (GO:0008236)
Orthologous Events
HTRA2 degrades NDUFA13 (GRIM-19) (Bos taurus)
HTRA2 degrades NDUFA13 (GRIM-19) (Canis familiaris)
HTRA2 degrades NDUFA13 (GRIM-19) (Drosophila melanogaster)
HTRA2 degrades NDUFA13 (GRIM-19) (Mus musculus)
HTRA2 degrades NDUFA13 (GRIM-19) (Rattus norvegicus)
HTRA2 degrades NDUFA13 (GRIM-19) (Sus scrofa)
Authored
May, B  (2023-06-27)
Reviewed
Houry, WA  (2023-11-04)
Morey, T  (2023-11-04)
Aljghami, ME  (2023-11-04)
Created
May, B  (2023-06-30)
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