Reactome | HTRA2 degrades APP (Amyloid-beta precursor protein)

HTRA2 degrades APP (Amyloid-beta precursor protein)

Stable Identifier

R-HSA-9839072

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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HTRA2 degrades APP (Amyloid-beta precursor protein)

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About 25-30% of cellular amyloid precursor protein isoform 695 (APP695) is located in mitochondria, where its accumulation can cause mitochondrial dysfunction (Anandatheerthavarada et al. 2003). HTRA2, located in the mitochondrial intermembrane space, cleaves APP695 to yield a 161 amino acid C-terminal fragment (C161) that is translocated to the cytosol (Park et al. 2006). The fate of the remaining 534 amino acid N-terminal fragment of the APP695 protein is unknown. The amyloid-beta cleavage product of APP, which is associated with Alzheimer's Disease, binds HTRA2 in the cytosol (Park et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
16968707	Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria Goo, HG, Min, do S, Yoon, EJ, Seong, YM, Kim, SS, Park, HJ, Kang, S, Kim, KH, Rhim, H	J Biol Chem	2006