Reactome | HTRA2 degrades APP (Amyloid-beta precursor protein)

HTRA2 degrades APP (Amyloid-beta precursor protein)

Stable Identifier

R-HSA-9839072

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

HTRA2 degrades APP (Amyloid-beta precursor protein)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

About 25-30% of cellular amyloid precursor protein isoform 695 (APP695) is located in mitochondria, where its accumulation can cause mitochondrial dysfunction (Anandatheerthavarada et al. 2003). HTRA2, located in the mitochondrial intermembrane space, cleaves APP695 to yield a 161 amino acid C-terminal fragment (C161) that is translocated to the cytosol (Park et al. 2006). The fate of the remaining 534 amino acid N-terminal fragment of the APP695 protein is unknown. The amyloid-beta cleavage product of APP, which is associated with Alzheimer's Disease, binds HTRA2 in the cytosol (Park et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
16968707	Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria Park, HJ, Kim, SS, Seong, YM, Kim, KH, Goo, HG, Yoon, EJ, Min, do S, Kang, S, Rhim, H	J Biol Chem	2006