Abortive replication of hRSV A

Stable Identifier
R-HSA-9837511
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Abortive replication of hRSV A
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
During replication, human respiratory syncytial virus (RSV) A, similar to other negative sense RNA viruses, generates defective viral genomes (DVGs) as byproducts. DVGs have immunostimulatory effects, and were therefore originally called immunostimulatory DVGs (iDVGs) (Sun et al. 2015). Due to the underlying mechanism for generation of iDVGs in negative sense, single stranded RNA viruses, which involves slipping of viral RNA-driven RNA polymerase (RdRP) complex from the antigenome (+) template and then resuming of synthesis by copying the 5’ portion of the daughter strand that it is synthesizing (copy-back), iDVGs are called copy-back viral genomes (cbVGs) and are characterized by the presence of double-stranded regions (Lazzarini et al. 1981). Accumulation and diversification of cbVGs affects viral replication and response of the host's immune system to the infection (Felt et al. 2022).
Literature References
PubMed ID Title Journal Year
36325033 Accumulation of copy-back viral genomes during respiratory syncytial virus infection is preceded by diversification of the copy-back viral genome population followed by selection

Felt, SA, Achouri, E, Faber, SR, López, CB

Virus Evol 2022
26336095 Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans

Sun, Y, Jain, D, Koziol-White, CJ, Genoyer, E, Gilbert, M, Tapia, K, Panettieri, RA, Hodinka, RL, López, CB

PLoS Pathog 2015
7037195 The origins of defective interfering particles of the negative-strand RNA viruses

Lazzarini, RA, Keene, JD, Schubert, M

Cell 1981
Participants
Input
Output
Participates
as an event of
Catalyst Activity

RNA-directed RNA polymerase activity of RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol]

Physical Entity
RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol] (Human respiratory syncytial virus A)
Activity
RNA-directed RNA polymerase activity (GO:0003968)
Disease
Cross References
Mondo
Authored
Orlic-Milacic, M  (2023-06-16)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-06-15)
Cite Us!