Formation of hRSV A dsRNA intermediate form

Stable Identifier
R-HSA-9837448
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Formation of hRSV A dsRNA intermediate form
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Based on findings that replication of human respiratory syncytial virus (RSV) A can be inhibited by components of the innate immune system that sense double-stranded RNA (dsRNA), such as OAS2 (Behera et al. 2002), dsRNA intermediates are believed to be produced during RSV replication in host cells (reviewed in van Royen et al. 2022). Considering that packaging of RSV antigenomic RNA occurs concurrently with replication (Cirino et al. 1997; McGivern et al. 2005), that antigenomic RNA is produced in much smaller quantities than genomic RNA (Blanchard et al. 2020), and that existence of RSV genomic dsRNA intermediates has not been explicitly demonstrated experimentally, such intermediates are likely produced in small amounts, possibly as byproducts of viral replication.

Instead of acting on genomic dsRNA intermediates, OAS2 may target dsRNA segments in the secondary structure of RSV mRNAs, in particular M2-2 mRNA (Cirino et al. 1997).
Literature References
PubMed ID Title Journal Year
11980899 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells

Behera, AK, Kumar, M, Lockey, RF, Mohapatra, SS

J. Biol. Chem. 2002
9050883 Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells

Cirino, NM, Li, G, Xiao, W, Torrence, PF, Silverman, RH

Proc Natl Acad Sci U S A 1997
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Mondo
Authored
Orlic-Milacic, M  (2023-06-16)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-06-15)
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