FASTKD2 binds 16S rRNA and MT-ND6 mRNA

Stable Identifier
R-HSA-9837212
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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FASTKD2 binds 16S rRNA and MT-ND6 mRNA
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Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) binds 16S rRNA (Antonicka and Shoubridge 2015, Popow et al. 2015) and the coding region of the MT-ND6 mRNA, which encodes a subunit of NADH dehydrogenase (Popow et al. 2015). Deletion of FASTKD2 causes aberrant processing and reduced expression of 16S rRNA and MT-ND6 mRNA (Popow et al. 2015). FASTKD2 interacts with RNA granule proteins, ribosomal proteins, MTERFD1, TRUB2, WBSCR16, and NGRN (Antonicka et al. 2017). Mutations in FASTKD2 are associated with deficiencies in oxidative phosphorylation complexes and impaired mitochondrial function (Wei et al. 2020).
Literature References
PubMed ID Title Journal Year
26370583 FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation

Sauer, S, Curk, T, Schwarzl, T, Alleaume, AM, Hentze, MW, Popow, J

RNA 2015
25683715 Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

Antonicka, H, Shoubridge, EA

Cell Rep 2015
Participants
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Output
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Authored
May, B  (2023-06-08)
Reviewed
Anonymous, R  (2023-08-09)
Created
May, B  (2023-06-10)
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