FASTK binds MT-ND6 mRNA

Stable Identifier
R-HSA-9837087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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FASTK binds MT-ND6 mRNA
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The mitochondrial form of FASTK binds several sites in the 3' UTR of the MT-ND6 mRNA and precursors of the MT-ND6 mRNA and prevents degradation of the RNAs by the degradosome (SUPV3L1:PNPT1) (Jourdain et al. 2015). Absence of FASTK results in much lower levels of MT-ND6 mRNA and reduced activity of the NADH dehydrogenase complex (Jourdain et al. 2015).
Literature References
PubMed ID Title Journal Year
25704814 A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function

Jourdain, AA, Koppen, M, Rodley, CD, Maundrell, K, Gueguen, N, Reynier, P, Guaras, AM, Enriquez, JA, Anderson, P, Simarro, M, Martinou, JC

Cell Rep 2015
Participants
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Output
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as an event of
Authored
May, B  (2023-06-08)
Reviewed
Anonymous, R  (2023-08-09)
Created
May, B  (2023-06-08)
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