Reactome | SYK autophosphorylates at the activated BCR

SYK autophosphorylates at the activated BCR

Stable Identifier

R-HSA-983707

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Autophosphorylation of SYK at the Activated B Cell Receptor

ReviewStatus

5/5

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SYK autophosphorylates at the activated BCR

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SHP1 regulates BCR signaling by dephosphorylating CD79A/CD79B (IGA/IGB) and its downstream signaling molecules SYK and SLP65 promoting Ca2+ efflux from the cell9 (Adachi et al. 2001, Chen et al. 2004).

The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21469132	Complex phosphorylation dynamics control the composition of the Syk interactome in B cells Urlaub, H, Engelke, M, Oellerich, T, Wienands, J, Hsiao, HH, Bohnenberger, H	Eur J Immunol	2011
7538118	Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation Chao, HG, Bolen, JB, Burkhardt, AL, Rowley, RB, Matsueda, GR	J Biol Chem	1995
18052078	Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay Shaw, D, Wang, S, Papp, E, Lee, S, Tse, JK, Swinney, DC, Barnett, J, Ho, H, Bradshaw, JM	Biochemistry	2007
16849466	Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry Nolan, GP, Irish, JM, Czerwinski, DK, Levy, R	J Immunol	2006
10648173	Purification and characterization of human Syk produced using a baculovirus expression system Akhlaq, M, Graham, B, Jones, CE, Graff, P, Menear, K, Baldock, D	Protein Expr Purif	2000
18006696	SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma Chen, W, Habermann, TM, Monti, S, Shipp, MA, Kutok, JL, Daley, J, Juszczynski, P, Witzig, TE, Chen, L	Blood	2008
18818202	Molecular mechanism of the Syk activation switch Shaw, D, Papp, E, Gandhi, S, Tsang, E, Giannetti, AM, Tse, JK, Dinh, M, Wang, S, Ho, H, Bradshaw, JM	J Biol Chem	2008
8163536	Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex Chandran, KA, Law, CL, Clark, EA, Weiss, A, Chan, AC, Sidorenko, SP, Edelhoff, S, Draves, KE, Disteche, CM	J Biol Chem	1994