Reactome | SYK autophosphorylates at the activated BCR

SYK autophosphorylates at the activated BCR

Stable Identifier

R-HSA-983707

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Autophosphorylation of SYK at the Activated B Cell Receptor

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SYK autophosphorylates at the activated BCR

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The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
7538118	Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation Rowley, RB, Burkhardt, AL, Chao, HG, Matsueda, GR, Bolen, JB	J Biol Chem	1995
21469132	Complex phosphorylation dynamics control the composition of the Syk interactome in B cells Bohnenberger, H, Oellerich, T, Engelke, M, Hsiao, HH, Urlaub, H, Wienands, J	Eur J Immunol	2011
18052078	Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay Papp, E, Tse, JK, Ho, H, Wang, S, Shaw, D, Lee, S, Barnett, J, Swinney, DC, Bradshaw, JM	Biochemistry	2007
16849466	Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry Irish, JM, Czerwinski, DK, Nolan, GP, Levy, R	J Immunol	2006
10648173	Purification and characterization of human Syk produced using a baculovirus expression system Baldock, D, Graham, B, Akhlaq, M, Graff, P, Jones, CE, Menear, K	Protein Expr Purif	2000
18006696	SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma Chen, L, Monti, S, Juszczynski, P, Daley, J, Chen, W, Witzig, TE, Habermann, TM, Kutok, JL, Shipp, MA	Blood	2008
18818202	Molecular mechanism of the Syk activation switch Tsang, E, Giannetti, AM, Shaw, D, Dinh, M, Tse, JK, Gandhi, S, Ho, H, Wang, S, Papp, E, Bradshaw, JM	J Biol Chem	2008
8163536	Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex Law, CL, Sidorenko, SP, Chandran, KA, Draves, KE, Chan, AC, Weiss, A, Edelhoff, S, Disteche, CM, Clark, EA	J Biol Chem	1994