SYK autophosphorylates at the activated BCR

Stable Identifier
R-HSA-983707
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Autophosphorylation of SYK at the Activated B Cell Receptor
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SHP1 regulates BCR signaling by dephosphorylating CD79A/CD79B (IGA/IGB) and its downstream signaling molecules SYK and SLP65 promoting Ca2+ efflux from the cell9 (Adachi et al. 2001, Chen et al. 2004).

The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011).

Literature References
PubMed ID Title Journal Year
21469132 Complex phosphorylation dynamics control the composition of the Syk interactome in B cells

Urlaub, H, Engelke, M, Oellerich, T, Wienands, J, Hsiao, HH, Bohnenberger, H

Eur J Immunol 2011
7538118 Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

Chao, HG, Bolen, JB, Burkhardt, AL, Rowley, RB, Matsueda, GR

J Biol Chem 1995
18052078 Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay

Shaw, D, Wang, S, Papp, E, Lee, S, Tse, JK, Swinney, DC, Barnett, J, Ho, H, Bradshaw, JM

Biochemistry 2007
16849466 Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry

Nolan, GP, Irish, JM, Czerwinski, DK, Levy, R

J Immunol 2006
10648173 Purification and characterization of human Syk produced using a baculovirus expression system

Akhlaq, M, Graham, B, Jones, CE, Graff, P, Menear, K, Baldock, D

Protein Expr Purif 2000
18006696 SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Chen, W, Habermann, TM, Monti, S, Shipp, MA, Kutok, JL, Daley, J, Juszczynski, P, Witzig, TE, Chen, L

Blood 2008
18818202 Molecular mechanism of the Syk activation switch

Shaw, D, Papp, E, Gandhi, S, Tsang, E, Giannetti, AM, Tse, JK, Dinh, M, Wang, S, Ho, H, Bradshaw, JM

J Biol Chem 2008
8163536 Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex

Chandran, KA, Law, CL, Clark, EA, Weiss, A, Chan, AC, Sidorenko, SP, Edelhoff, S, Draves, KE, Disteche, CM

J Biol Chem 1994
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane]

This event is regulated
Orthologous Events
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