SYK autophosphorylates at the activated BCR

Stable Identifier
Reaction [transition]
Homo sapiens
Autophosphorylation of SYK at the Activated B Cell Receptor
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The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011).

Literature References
PubMed ID Title Journal Year
7538118 Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

Rowley, RB, Burkhardt, AL, Chao, HG, Matsueda, GR, Bolen, JB

J Biol Chem 1995
21469132 Complex phosphorylation dynamics control the composition of the Syk interactome in B cells

Bohnenberger, H, Oellerich, T, Engelke, M, Hsiao, HH, Urlaub, H, Wienands, J

Eur J Immunol 2011
18052078 Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay

Papp, E, Tse, JK, Ho, H, Wang, S, Shaw, D, Lee, S, Barnett, J, Swinney, DC, Bradshaw, JM

Biochemistry 2007
16849466 Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry

Irish, JM, Czerwinski, DK, Nolan, GP, Levy, R

J Immunol 2006
10648173 Purification and characterization of human Syk produced using a baculovirus expression system

Baldock, D, Graham, B, Akhlaq, M, Graff, P, Jones, CE, Menear, K

Protein Expr Purif 2000
18006696 SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Chen, L, Monti, S, Juszczynski, P, Daley, J, Chen, W, Witzig, TE, Habermann, TM, Kutok, JL, Shipp, MA

Blood 2008
18818202 Molecular mechanism of the Syk activation switch

Tsang, E, Giannetti, AM, Shaw, D, Dinh, M, Tse, JK, Gandhi, S, Ho, H, Wang, S, Papp, E, Bradshaw, JM

J Biol Chem 2008
8163536 Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex

Law, CL, Sidorenko, SP, Chandran, KA, Draves, KE, Chan, AC, Weiss, A, Edelhoff, S, Disteche, CM, Clark, EA

J Biol Chem 1994
Participant Of
Catalyst Activity
Catalyst Activity
protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane]
Physical Entity
This event is regulated
Orthologous Events
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