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NS1 (1C) binds H2BC15
Stable Identifier
R-HSA-9837063
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
nucleoplasm
ReviewStatus
5/5
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Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
NS1 (1C) binds H2BC15 (Homo sapiens)
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The 1C (NS1) protein of hRSV binds to histone H2B type 1-N (H2B1N, H2BD, H2BC15) in the nucleus, inducing histone ubiquitination and affecting subsequent HOX gene expression (Tan et al, 2013).
Literature References
PubMed ID
Title
Journal
Year
23054021
Nonstructural protein-1 of respiratory syncytial virus regulates HOX gene expression through interacting with histone
Tan, YR
,
Chen, CM
,
Peng, D
,
Qin, XQ
Mol Biol Rep
2013
Participants
Input
HIST1H2BN [nucleoplasm]
(Homo sapiens)
NS1 [nucleoplasm]
(Human respiratory syncytial virus A)
Output
HIST1H2BN:NS1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RSV-host interactions (Homo sapiens)
Disease
Name
Identifier
Synonyms
respiratory syncytial virus infectious disease
DOID:1273
Authored
Stephan, R (2023-06-08)
Reviewed
Bergeron, HC (2023-11-03)
Created
Stephan, R (2023-06-08)
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