Reactome | p-6Y-SYK phosphorylates BLNK (SLP65)

p-6Y-SYK phosphorylates BLNK (SLP65)

Stable Identifier

R-HSA-983703

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11909947	The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways Aebersold, R, Skaggs, BJ, Affolter, M, Siemasko, K, Gold, MR, Chan, AC, Foster, MS, Kabak, S, Clark, MR, West, KL	Mol Cell Biol	2002
11449366	Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha Wienands, J, Engels, N, Wollscheid, B	Eur J Immunol	2001
11071869	Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes Watanabe, S, Iwata, N, Take, H, Kajigaya, S, Yu, ZX, Takeda, K	Biochem Biophys Res Commun	2000
9705962	SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation Reth, M, Nielsen, PJ, Schweikert, J, Wienands, J, Jumaa, H, Wollscheid, B	J Exp Med	1998
9341187	Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation Chan, AC, Fu, C	J Biol Chem	1997
19372136	SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins Urlaub, H, Oellerich, T, Wienands, J, Grønborg, M, Hsiao, HH, Neumann, K	Mol Cell Proteomics	2009
12456653	BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins Dalton, M, Chiu, CW, Ishiai, M, Chan, AC, Kurosaki, T	EMBO J	2002
9697839	BLNK: a central linker protein in B cell activation Turck, CW, Chan, AC, Kurosaki, T, Fu, C	Immunity	1998
21822214	The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 Urlaub, H, Batista, FD, Engelke, M, Bremes, V, Oellerich, T, Wienands, J, Dittmann, K, Schnyder, T, Hsiao, HH, Bohnenberger, H, Neumann, K	EMBO J	2011