sG binds to HSPGs

Stable Identifier
R-HSA-9836899
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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sG binds to HSPGs
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The secreted soluble isoform of hRSV G protein (sG) binds to proteoglycans on the surface of host cells (Escribano-Romero et al, 2004). sG has been reported to enhance cytotoxic T-cell responses in mice, act as an antigen decoy, and modulate Fc-mediated antibody anti-viral activity (reviewed by Anderson et al, 2021).
Literature References
PubMed ID Title Journal Year
15016875 The soluble form of human respiratory syncytial virus attachment protein differs from the membrane-bound form in its oligomeric state but is still capable of binding to cell surface proteoglycans

Escribano-Romero, E, García-Barreno, B, Melero, JA, Rawling, J

J Virol 2004
34372490 Functional Features of the Respiratory Syncytial Virus G Protein

Paden, CR, Jadhao, SJ, Tong, S, Anderson, LJ

Viruses 2021
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Output
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as an event of
Disease
Authored
Stephan, R  (2023-06-05)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-06-06)
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