p-PKR dimer phosphorylates PTPN2

Stable Identifier
R-HSA-9836515
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-PKR dimer phosphorylates PTPN2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Protein kinase R (PKR, EIF2AK2) phosphorylates the tyrosine-protein phosphatase PTPN2 (TCPTP) on an unknown residue. It is unclear if this directly affects the catalytic activity of PTPN2 (Wang et al, 2006).
Literature References
PubMed ID Title Journal Year
16431927 The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase

Wang, S, Raven, JF, Baltzis, D, Kazemi, S, Brunet, DV, Hatzoglou, M, Tremblay, ML, Koromilas, AE

J Biol Chem 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase activity of p-EIF2AK2 dimer [cytosol]

Physical Entity
p-EIF2AK2 dimer [cytosol] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Orthologous Events
p-PKR dimer phosphorylates PTPN2 (Bos taurus)
p-PKR dimer phosphorylates PTPN2 (Canis familiaris)
p-PKR dimer phosphorylates PTPN2 (Danio rerio)
p-PKR dimer phosphorylates PTPN2 (Drosophila melanogaster)
p-PKR dimer phosphorylates PTPN2 (Gallus gallus)
p-PKR dimer phosphorylates PTPN2 (Mus musculus)
p-PKR dimer phosphorylates PTPN2 (Rattus norvegicus)
p-PKR dimer phosphorylates PTPN2 (Sus scrofa)
Authored
Stephan, R  (2023-05-29)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-30)
Cite Us!