Reactome | p-PTPN2 [cytosol]

p-PTPN2 [cytosol]

Stable Identifier

R-HSA-9836510

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TC-PTPb, Tyrosine-protein phosphatase non-receptor type 2, PTN2_HUMAN, TC48

Locations in the PathwayBrowser for interactor UniProt:Q9P296 C5AR2

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External Reference Information

External Reference

UniProt:P17706 PTPN2

Gene Names

PTPN2, PTPT

Chain

chain:1-415

Reference Genes

BioGPS Gene:5771 PTPN2

COSMIC (genes):PTPN2 PTPN2

CTD Gene:5771 PTPN2

dbSNP Gene:5771 PTPN2

ENSEMBL:ENSG00000175354 PTPN2

HGNC:9650 PTPN2

KEGG:hsa:5771 PTPN2

Monarch:5771 PTPN2

NCBI Gene:5771 PTPN2

OMIM:176887 PTPN2

UCSC:P17706 PTPN2

Reference Transcript

Participates

as an output of

p-PKR dimer phosphorylates PTPN2 (Homo sapiens)

Other forms of this molecule

PTPN2 [nucleoplasm]

PTPN2 [cytosol]

Inferred To

phospho-PTPN2 [cytosol] (Bos taurus)

phospho-PTPN2 [cytosol] (Sus scrofa)

phospho-Ptpn2 [cytosol] (Mus musculus)

phospho-Ptpn2 [cytosol] (Rattus norvegicus)

phospho-Ptp61F [cytosol] (Drosophila melanogaster)

phospho-p-PTPN2 [cytosol] (Canis familiaris)

phospho-p-PTPN2 [cytosol] (Gallus gallus)

phospho-ptpn2b [cytosol] (Danio rerio)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_002819.2, NP_001193942.1, NP_536348.1, NP_536347.1

Guide to Pharmacology - Targets

3255

OpenTargets

ENSG00000175354

ENSEMBL

ENSP00000320298, ENSG00000175354, ENSP00000320546, ENSP00000466936, ENSP00000311857, ENST00000309660, ENST00000353319, ENST00000591115, ENST00000327283

ZINC - Substances

PTN2_HUMAN

ZINC - Biogenic

PTN2_HUMAN

ZINC target

P17706

PRO

P17706

GlyGen

P17706

PDB

1L8K, 6ZZ4, 7F5N, 9C55, 7UAD, 8U0H, 9C54, 9C56, 7F5O, 8UH6

ZINC - Metabolites

PTN2_HUMAN

HPA

ENSG00000175354-PTPN2

GeneCards

PTPN2

Pharos - Targets

P17706

Orphanet

PTPN2

ZINC - Predictions - Purchasable

PTN2_HUMAN

HMDB Protein

HMDBP08934

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10912 GHR	7	GHR activated [plasma membrane] (R-HSA-1168385) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [endosome lumen] (R-HSA-1169263) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226)	0.645	8
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.643	3
UniProt:O43505 B4GAT1	1	B4GAT1 [Golgi membrane] (R-HSA-916821)	0.643	4
UniProt:P20908 COL5A1	20	3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663)	0.589	2
UniProt:Q2GHU2 Q2GHU2			0.557	4
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	2
UniProt:P07306 ASGR1	1	PALM-C36-ASGR1 [plasma membrane] (R-HSA-8855714)	0.527	2
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [specific granule membrane] (R-HSA-6799516) C3AR1 [azurophil granule membrane] (R-HSA-6799517)	0.527	2
UniProt:Q6P5W5 SLC39A4	9	SLC39A4 [plasma membrane] (R-HSA-442399) SLC39A4 1223_1227del [plasma membrane] (R-HSA-5654119) SLC39A4 L549del [plasma membrane] (R-HSA-5654135) SLC39A4 G330D [plasma membrane] (R-HSA-5654117) SLC39A4 P200L [plasma membrane] (R-HSA-5654131) SLC39A4 Q323Qfs*25 [plasma membrane] (R-HSA-5654109) SLC39A4 G512W [plasma membrane] (R-HSA-5654106) SLC39A4 G526R [plasma membrane] (R-HSA-5654120) SLC39A4 R95C [plasma membrane] (R-HSA-5654137)	0.527	2
UniProt:P56199 ITGA1	1	ITGA1 [plasma membrane] (R-HSA-215939)	0.463	2

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