Reactome | IKK complex is activated by PKR

IKK complex is activated by PKR

Stable Identifier

R-HSA-9836500

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Protein kinase R (PKR, EIF2AK2), through its catalytic domain in the N-terminus, binds to the IKK complex, activating it by enhancing the autophosphorylation of IKBKB. It is unclear whether PKR itself needs to be in its activated form for this process. The activated IKK complex subsequently activates NFkappa-B by phosphorylating its inhibitors (Chu et al, 1999; Bonnet et al, 2000; Gil et al, 2001: Zamanian-Daryoush et al, 2000; Bonnett et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
11313968	The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation Esteban, M, Rullas, J, Gil, J, García, MA, Alcamí, J	Oncogene	2001
10848580	PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex Bonnet, MC, Hovanessian, AG, Meurs, EF, Weil, R, Dam, E	Mol Cell Biol	2000
16600570	The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex Ottone, C, Daurat, C, Bonnet, MC, Meurs, EF	Cell Signal	2006
10648614	NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase Zamanian-Daryoush, M, Williams, BR, DiDonato, JA, Mogensen, TH	Mol Cell Biol	2000
10626894	JNK2 and IKKbeta are required for activating the innate response to viral infection Karin, M, Chang, L, Chu, WM, Ostertag, D, Williams, B, Hu, Y, Chen, Y, Li, ZW, Perrault, J	Immunity	1999