p-PKR dimer phosphorylates MAPT

Stable Identifier
R-HSA-9836404
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-PKR dimer phosphorylates MAPT
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Activated PKR phosphorylates the 2N4F isoform of microtubule-associated protein tau (tau-F, tau-8, MAPT-8) at several serine and threonine residues. In neurons phosphorylated tau dissociates from microtubules, leaving them unstable, and accumulates outside the axon. Accumulation and self-assembly of tau are parts of so-called tau pathology in several neurodegenerative diseases (Reimer et al, 2021).
Literature References
PubMed ID Title Journal Year
32716602 PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation

Volbracht, C, Överby, AK, Betzer, C, Kurhade, C, Kofoed, RH, Nilsson, E, Fog, K, Reimer, L, Jensen, PH

Brain Pathol 2021
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Output
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as an event of
Catalyst Activity

protein kinase activity of p-EIF2AK2 dimer [cytosol]

Physical Entity
p-EIF2AK2 dimer [cytosol] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Orthologous Events
p-PKR dimer phosphorylates MAPT (Canis familiaris)
p-PKR dimer phosphorylates MAPT (Mus musculus)
p-PKR dimer phosphorylates MAPT (Rattus norvegicus)
p-PKR dimer phosphorylates MAPT (Sus scrofa)
Authored
Stephan, R  (2023-05-27)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-27)
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