Reactome | p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]

p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]

Stable Identifier

R-HSA-9836400

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Microtubule-associated protein tau, Isoform Tau-F, TAU_HUMAN, Tau-F, Tau-4

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Locations in the PathwayBrowser for interactor UniProt:P23284 PPIB

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External Reference Information

External Reference

UniProt:P10636-8 MAPT

Gene Names

MAPT, MAPTL, MTBT1, TAU

Other Identifiers

113_i_at

114_r_at

11718731_a_at

11718732_a_at

11718733_a_at

11722667_a_at

11747246_a_at

11763486_a_at

16835016

203928_PM_x_at

203928_x_at

203929_PM_s_at

203929_s_at

203930_PM_s_at

203930_s_at

206401_PM_s_at

206401_s_at

225379_PM_at

225379_at

310_s_at

331_at

3723688

3723707

3723710

3723712

3723714

3723721

3723722

3723723

3723725

3723731

3723732

3723733

3723734

3723735

3723736

3723737

3723740

3723743

3723746

3723747

3723748

3723749

3723750

3723751

3723752

3723753

3723754

3723759

38629_at

4137

8007828

80210_at

A_14_P115066

A_14_P130889

A_14_P132491

A_21_P0014031

A_23_P207699

A_24_P224488

A_32_P95541

GE58740

GE86145

GO:0000226

GO:0001774

GO:0002376

GO:0003677

GO:0003680

GO:0003690

GO:0003697

GO:0003723

GO:0003779

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0006475

GO:0006914

GO:0006919

GO:0006954

GO:0006974

GO:0007005

GO:0007010

GO:0007018

GO:0007267

GO:0007416

GO:0007611

GO:0007613

GO:0008017

GO:0008092

GO:0008289

GO:0010288

GO:0010506

GO:0010629

GO:0010917

GO:0015630

GO:0015631

GO:0016020

GO:0016072

GO:0016607

GO:0017124

GO:0019896

GO:0019899

GO:0019901

GO:0021954

GO:0023052

GO:0030154

GO:0030424

GO:0030425

GO:0030426

GO:0030673

GO:0030674

GO:0031110

GO:0031113

GO:0031116

GO:0031122

GO:0031175

GO:0032930

GO:0033044

GO:0033673

GO:0034063

GO:0034185

GO:0034330

GO:0034399

GO:0034452

GO:0034605

GO:0034614

GO:0035091

GO:0036211

GO:0036464

GO:0036477

GO:0042802

GO:0042995

GO:0043005

GO:0043025

GO:0043197

GO:0043226

GO:0043565

GO:0044297

GO:0044304

GO:0045121

GO:0045298

GO:0045773

GO:0046785

GO:0048143

GO:0048167

GO:0048312

GO:0048699

GO:0048856

GO:0050808

GO:0050848

GO:0050877

GO:0051087

GO:0051258

GO:0051260

GO:0051721

GO:0051879

GO:0060090

GO:0061564

GO:0065003

GO:0070507

GO:0071813

GO:0072386

GO:0090140

GO:0090258

GO:0097386

GO:0097418

GO:0097435

GO:0098930

GO:0099077

GO:0099609

GO:1900034

GO:1900452

GO:1902474

GO:1902936

GO:1902988

GO:1903748

GO:1903829

GO:1904115

GO:1904428

GO:1905689

GO:1990000

GO:1990090

GO:1990416

HMNXSV003034099

Hs.101174.4.A1_3p_at

ILMN_1710903

ILMN_2298727

ILMN_2310814

J03778_s_at

PH_hs_0005629

TC17000592.hg

TC17002241.hg

TC17_ctg5_hap1000017.hg

X14474_at

X61373_at

g338684_3p_a_at

g8400712_3p_a_at

Participates

as an output of

p-PKR dimer phosphorylates MAPT (Homo sapiens)

Other forms of this molecule

p-S262,S356,S396-MAPT-8 [cytosol]

MAPT-8 [cytosol]

Inferred To

phospho-p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (Dictyostelium discoideum)

phospho-Mapt [cytosol] (Mus musculus)

phospho-Mapt [cytosol] (Rattus norvegicus)

phospho-MAPT [cytosol] (Canis familiaris)

phospho-MAPT [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 181

Coordinate

181

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 199

Coordinate

199

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 202

Coordinate

202

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 231

Coordinate

231

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 262

Coordinate

262

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 396

Coordinate

396

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 404

Coordinate

404

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 409

Coordinate

409

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_058519.3, NP_058518.1, NP_001190181.1, NP_005901.2, NP_001116538.2, NP_058525.1, NP_001116539.1

ZINC - World Drugs

TAU_HUMAN

OpenTargets

ENSG00000186868

ZINC - FDA approved

TAU_HUMAN

ZINC - Substances

TAU_HUMAN

ZINC - Biogenic

TAU_HUMAN

ZINC target

P10636

PRO

P10636

PDB

5ZV3, 8SEH, 8Q8R, 7QK2, 8Q9G, 7P68, 7QKF, 5ZIA, 7QKZ, 8OHP, 8Q8X, 3OVL, 5E2W, 8FUG, 6GK7, 7SP1, 7NRS, 8OTH, 8Q99, 8Q9I, 7QJX, 8Q8D, 8BGS, 6FBW, 5N5B, 7P6D, 2ON9, 8P34, 6QJP, 4Y5I, 6TJX, 8Q2L, 6QJH, 7UPE, 8OI0, 8ORG, 7QKL, 6BB4, 5HF3, 7EYC, 7P65, 8OPI, 8Q98, 7QKY, 8PII, 7QJW, 8OHI, 8Q9C, 5DMG, 6DCA, 7P6C, 8Q9M, 7P67, 8Q9F, 7QJZ, 8ORF, 4GLR, 7QKK, 8OP0, 6N4P, 8Q9E, 8Q8C, 5MO3, 7YPG, 8Q8W, 7QK6, 6QJM, 6DC8, 5MP5, 8G58, 8CAX, 5MP3, 8Q7L, 6QJQ, 7QL3, 5N5A, 6PXR, 7PQP, 8Q2K, 7U0Z, 7QL4, 7QK1, 8Q7M, 6CVJ, 5O3T, 8OT9, 8Q9K, 6VH7, 8Q8M, 8QCR, 7NRX, 7R5H, 8Q7F, 6HRF, 8Q8L, 7NRQ, 5O3L, 4NP8, 6NWP, 8Q8F, 8QJJ, 7QKU, 8ORE, 8OTJ, 6ODG, 7QJV, 8Q9B, 7R4T, 6GK8, 8Q27, 7QK5, 8OTG, 8Q88, 6FI5, 6LRA, 8Q9D, 7QKX, 8Q7T, 7MKG, 7UPG, 6HRE, 6CVN, 7NRV, 4Y3B, 8Q97, 5V5C, 6XLI, 7KQK, 7P6B, 4E0O, 8G55, 8Q8U, 6VI3, 7QKH, 7MKH, 8OH2, 5O3O, 8R3T, 8BYN, 8KDX, 6TJO, 8Q8Z, 7QL2, 6NWQ, 7QKI, 4E0M, 8Q2J, 6GX5, 8AZU, 8Q8Y, 8Q8E, 8BGV, 7MKF, 8Q9H, 7QK3, 8OTC, 4E0N, 7QKV, 8G54, 6VHA, 7QL0, 8Q9L, 8CAQ, 7QKG, 7PQC, 8Q7P, 7QJY, 7QKW, 5NVB, 8Q9A, 4Y32, 7P6A, 7P6E, 7QKM, 7YMN, 8OTI, 4TQE, 5K7N, 8SEI, 7QKJ, 5MP1, 8FYU, 2MZ7, 8OT6, 1I8H, 6DC9, 7NRT, 8FNZ, 7P66, 8Q8V, 4FL5, 6NK4, 5V5B, 7QL1, 8Q9J, 5E2V, 8Q8S, 6H06, 8PPO, 7UPF, 8QCP, 8Q92, 8Q9O, 6VHL

ZINC - Investigational

TAU_HUMAN

ZINC - Metabolites

TAU_HUMAN

HPA

ENSG00000186868-MAPT

GeneCards

P10636

Ensembl

ENST00000703922, ENST00000620818, ENSP00000515557, ENSP00000408975, ENSP00000479142, ENSP00000443028, ENST00000574436, ENST00000622728, ENSP00000481769, ENST00000334239, ENST00000628393, ENSG00000276155, ENSP00000483784, ENSP00000487819, ENSP00000413056, ENSP00000482244, ENSP00000303214, ENST00000613360, ENSP00000410838, ENST00000634049, ENSP00000487570, ENST00000351559, ENSP00000505258, ENST00000621329, ENSG00000186868, ENSP00000458742, ENST00000680542, ENST00000571987, ENSP00000488373, ENST00000633047, ENSP00000484491, ENST00000415613, ENST00000703924, ENSP00000487837, ENSP00000515558, ENSP00000389250, ENST00000612872, ENSP00000515559, ENST00000420682, ENST00000703978, ENSP00000484321, ENSP00000478602, ENSP00000477703, ENSP00000515600, ENST00000620981, ENST00000626571, ENST00000620070, ENST00000631447, ENST00000431008, ENST00000703923, ENSP00000460965, ENSP00000488245, ENST00000535772, ENSG00000277956, ENST00000446361, ENST00000632500, ENSP00000334886, ENST00000622106, ENSP00000486039

Pharos - Targets

P10636

ZINC - Predictions - Purchasable

TAU_HUMAN

Orphanet

16379

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.749	8
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.723	8
UniProt:P05067-PRO_0000000092 APP			0.71	5
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.673	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.667	6
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.656	4
IntAct:EBI-4399559 UBIQ			0.641	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.589	3
UniProt:O43583 DENR			0.564	2
UniProt:Q8TCE9 PPL13			0.556	3
UniProt:O15195-2 O151952			0.556	3
UniProt:Q92608-2 Q926082			0.556	3
UniProt:Q9HC96 CAPN10	1	CAPN10 [cytosol] (R-HSA-8848640)	0.556	3
UniProt:Q9C0A1 ZFHX2			0.556	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.547	2
UniProt:P02649-PRO_0000001987 APOE			0.544	3
UniProt:P51674 GPM6A			0.527	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.524	2
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.499	4
UniProt:Q9UNE7-1 STUB1			0.499	5
UniProt:Q9UPY8 MARE3			0.499	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.499	2
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.499	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.483	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.483	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.471	2
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.463	2
UniProt:P43004 SLC1A2	1	SLC1A2 [plasma membrane] (R-HSA-210459)	0.462	4

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