Reactome | Expression of DLX5 in the neural plate border

Expression of DLX5 in the neural plate border

Stable Identifier

R-HSA-9836059

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Expression of DLX5 in the neural plate border

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DLX5 is expressed in the anterior neural plate border and in prospective non-neural ectoderm (inferred from chicken and mouse homologs). BMP4 (Leung et al. 2013, Mimura et al. 2016, and inferred from chicken homologs in Sjödal et al. 2007) and FGF4 (inferred from chicken homologs) induce expression of DLX5. WNT signaling is also required to obtain expression of DLX5 in embryonic stem cells programmed to become neural crest cells (Mimura et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
26934293	Bone morphogenetic protein 4 promotes craniofacial neural crest induction from human pluripotent stem cells Mimura, S, Suga, M, Okada, K, Kinehara, M, Nikawa, H, Furue, MK	Int J Dev Biol	2016
23643939	Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells Leung, AW, Kent Morest, D, Li, JY	Dev Biol	2013