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TFAP2A:TFAP2B binds the GBX2 gene
Stable Identifier
R-HSA-9836034
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Specification of the neural plate border (Homo sapiens)
TFAP2A:TFAP2B binds the GBX2 gene (Homo sapiens)
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The TFAP2A:TFAP2B heterodimer binds 2.1 kb from the GBX2 gene (4.2 kb downstream of the transcription start site) and activates expression (inferred from chicken homologs in Rothstein and Simoes-Costa 2020). TFAP2A:TFAP2C heterodimers initiate expression of genes expressed in the neural plate border, then TFAP2A:TFAP2B heterodimers maintain expression during formation of the neural crest (inferred from chicken homologs in Rothstein and Simoes-Costa 2020).
Participants
Input
GBX2 gene [nucleoplasm]
(Homo sapiens)
TFAP2A:TFAP2B [nucleoplasm]
(Homo sapiens)
Output
TFAP2A:TFAP2B:GBX2 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Specification of the neural plate border (Homo sapiens)
Inferred From
TFAP2A:TFAP2B binds the GBX2 gene (Gallus gallus)
Authored
May, B (2023-05-18)
Reviewed
Patthey, C (2023-10-28)
Gunhaga, L (2023-10-28)
Created
May, B (2023-05-22)
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