Reactome | ADAR1 binds PKR

ADAR1 binds PKR

Stable Identifier

R-HSA-9835944

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Human double-stranded RNA-specific adenosine deaminase 1 (ADAR1) is part of the RNA editosome complex involved in editing host and viral dsRNA. It shuttles between cytosol and nucleus (Patterson & Samuel, 1995; Barraud et al, 2014). and can inhibit protein kinase R (PKR, EiF2AK2), leading to sustained protein translation. For this reason, ADAR1 shows proviral activity in some viral infections (VSV, measles), independent of its usually antiviral RNA editing function (Nie et al, 2007; Wang & Samuel, 2009; Toth et al, 2009; George et al, 2016; Chung et al, 2018). Interactions between ADAR1, PACT, and HIV Tat proteins diminish PKR activation during HIV infection. (Chukwurah et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
29395325	Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown Rosenberg, BR, Sun, T, Wu, X, Yu, Y, Calis, JJA, Sarbanes, SL, Rice, CM, Shilvock, AR, Hoffmann, HH, Dao Thi, VL, Chung, H	Cell	2018
26817845	Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses Ramaswami, G, Samuel, CE, Li, JB, George, CX	J Biol Chem	2016
7565688	Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Samuel, CE, Patterson, JB	Mol Cell Biol	1995
28167698	ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element Handy, I, Chukwurah, E, Patel, RC	Biochem J	2017
17079286	Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection Nie, Y, Hammond, GL, Yang, JH	J Virol	2007
24753571	A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1 Barraud, P, Banerjee, S, Jantsch, MF, Allain, FH, Mohamed, WI	Proc Natl Acad Sci U S A	2014
19733181	Adenosine deaminase ADAR1 increases gene expression at the translational level by decreasing protein kinase PKR-dependent eIF-2alpha phosphorylation Wang, Y, Samuel, CE	J Mol Biol	2009
19710021	RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR Cattaneo, R, Toth, AM, Samuel, CE, Li, Z	J Biol Chem	2009