HCMV TRS1 binds PKR dimer

Stable Identifier
R-HSA-9835940
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
ReviewStatus
5/5
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Human cytomegalovirus TRS1 protein binds protein kinase R (PKR, EIF2AK2), after its activation, and inhibits PKR kinase activity, promoting hCMV protein synthesis and replication (Braggin et al, 2016; Vincent et al, 2017).
Literature References
PubMed ID Title Journal Year
26716879 Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication

Braggin, JE, Child, SJ, Geballe, AP

Virology 2016
27974558 Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1

Ziehr, B, Vincent, HA, Moorman, NJ

J Virol 2017
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