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HCMV TRS1 binds PKR dimer
Stable Identifier
R-HSA-9835940
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
HCMV TRS1 binds PKR dimer (Homo sapiens)
General
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Human cytomegalovirus TRS1 protein binds protein kinase R (PKR, EIF2AK2), after its activation, and inhibits PKR kinase activity, promoting hCMV protein synthesis and replication (Braggin et al, 2016; Vincent et al, 2017).
Literature References
PubMed ID
Title
Journal
Year
26716879
Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication
Braggin, JE
,
Child, SJ
,
Geballe, AP
Virology
2016
27974558
Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1
Ziehr, B
,
Vincent, HA
,
Moorman, NJ
J Virol
2017
Participants
Input
p-EIF2AK2 dimer [cytosol]
(Homo sapiens)
TRS1 [cytosol]
(Human cytomegalovirus)
Output
TRS1:p-EIF2AK2 dimer [cytosol]
(Homo sapiens)
Participates
as an event of
PKR-mediated signaling (Homo sapiens)
Disease
Name
Identifier
Synonyms
human cytomegalovirus infection
DOID:0080827
Authored
Stephan, R (2023-05-15)
Reviewed
Patel, RC (2023-08-16)
Created
Stephan, R (2023-05-22)
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