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p-5Y-BLNK [plasma membrane]
Stable Identifier
R-HSA-983579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated B-cell linker protein (BLNK/SLP-65/BASH), BLNK, BLNK_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
BTK autophosphorylates (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
p-SYK and LYN phosphorylate BTK (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
LYN, p-SYK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
p-5Y-BLNK [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12456653
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins
Dalton, M
,
Chiu, CW
,
Ishiai, M
,
Chan, AC
,
Kurosaki, T
EMBO J
2002
External Reference Information
External Reference
UniProt:Q8WV28 BLNK
Gene Names
BLNK, BASH, SLP65
Chain
chain:1-456
Reference Genes
BioGPS Gene:29760 BLNK
COSMIC (genes):BLNK BLNK
CTD Gene:29760 BLNK
dbSNP Gene:29760 BLNK
ENSEMBL:ENSG00000095585 BLNK
HGNC:14211 BLNK
KEGG:hsa:29760 BLNK
Monarch:29760 BLNK
NCBI Gene:29760 BLNK
OMIM:604515 BLNK
UCSC:Q8WV28 BLNK
Reference Transcript
RefSeq:NM_001258440.1 BLNK
RefSeq:NM_013314.3 BLNK
RefSeq:NM_001114094.1 BLNK
Other Identifiers
11728530_a_at
16716918
207655_PM_s_at
207655_s_at
244172_PM_at
244172_at
2840623
2867272
2867281
29760
3136166
3259566
3301712
3301714
3301715
3301716
3301717
3301718
3301719
3301720
3301724
3301725
3301726
3301728
3301729
3301730
3301731
3301732
3301734
3301735
3301736
3301737
3301738
3301739
3301740
3301741
3301742
3301744
3301747
3301748
3301750
3301751
3301752
3301759
3301760
3404467
38242_at
68112_at
7896054
7896690
7896707
7935270
82175_at
89441_at
A_24_P565390
A_24_P64344
A_33_P3360525
A_33_P3363637
GE54604
GO:0002376
GO:0005068
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006954
GO:0006959
GO:0007169
GO:0008289
GO:0010628
GO:0016020
GO:0019899
GO:0019901
GO:0030154
GO:0030183
GO:0035556
GO:0035591
GO:0042113
GO:0042169
GO:0043226
GO:0043231
GO:0043274
GO:0050853
GO:0060090
GO:0140693
GO:1990782
HMNXSV003041213
HMNXSV003054708
Hs.270085.0.A1_3p_at
ILMN_2142935
PH_hs_0010061
TC10001555.hg
g7019534_3p_a_at
Participates
as a component of
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
Other forms of this molecule
BLNK [cytosol]
Inferred To
phospho-BLNK [plasma membrane]
(Bos taurus)
phospho-BLNK [plasma membrane]
(Canis familiaris)
phospho-BLNK [plasma membrane]
(Gallus gallus)
phospho-p-5Y-BLNK [plasma membrane]
(Sus scrofa)
phospho-Blnk [plasma membrane]
(Mus musculus)
phospho-Blnk [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 72
Coordinate
72
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 84
Coordinate
84
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 96
Coordinate
96
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 178
Coordinate
178
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 189
Coordinate
189
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001245369.1
,
NP_037446.1
,
NP_001107566.1
ENSEMBL
ENSP00000397487
,
ENST00000413476
,
ENST00000224337
,
ENSP00000360218
,
ENST00000371176
,
ENSP00000224337
OpenTargets
ENSG00000095585
HPA
ENSG00000095585-BLNK
PRO
Q8WV28
Pharos - Targets
Q8WV28
Orphanet
BLNK
PDB
6YLU
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.743
5
UniProt:Q06187 BTK
6
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
p-Y551-BTK [plasma membrane]
(R-HSA-9606165)
BTK [cytosol]
(R-HSA-197948)
p-Y551-BTK [cytosol]
(R-HSA-2685603)
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
Active BTK [cytosol]
(R-HSA-8964323)
0.667
4
UniProt:O89100 Grap2
2
Grap2 [cytosol]
(R-MMU-9680624)
Grap2 [cytosol]
(R-MMU-202367)
0.609
2
UniProt:Q5ZMQ7
3
Ub-SH3KBP1 [cytosol]
(R-GGA-182926)
SH3KBP1 [cytosol]
(R-GGA-182957)
SH3KBP1 [plasma membrane]
(R-GGA-182955)
0.558
3
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.499
2
UniProt:Q5ZJW0 Q5ZJW0
0.462
2
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