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TFAP2A:TFAP2C, POU5F1, SOX2 and MYB bind the PAX7 gene
Stable Identifier
R-HSA-9835484
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Specification of the neural plate border (Homo sapiens)
TFAP2A:TFAP2C, POU5F1, SOX2 and MYB bind the PAX7 gene (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The TFAP2A:TFAP2C heterodimer binds the PAX7 gene and activates expression (inferred from chicken homologs in Rothstein and Simoes-Costa 2020). POU5F1 (OCT4) and SOX2 also bind near the PAX7 gene (inferred from chicken homologs in Hovland et al. 2022). SOX2 and TFAP2A may interact. MYB binds an enhancer upstream of PAX7 which activates expression in the neural plate border but not in somites (mesoderm) (inferred from chicken homologs in Vadasz et al. 2013).
Participants
Input
MYB [nucleoplasm]
(Homo sapiens)
PAX7 gene [nucleoplasm]
(Homo sapiens)
POU5F1 [nucleoplasm]
(Homo sapiens)
SOX2 [nucleoplasm]
(Homo sapiens)
TFAP2A:TFAP2C [nucleoplasm]
(Homo sapiens)
Output
TFAP2A:TFAP2C:POU5F1:SOX2:MYB:PAX7 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Specification of the neural plate border (Homo sapiens)
Inferred From
MYB binds the PAX7 gene (Gallus gallus)
POU5F3 and SOX2 binds the PAX7 gene (Gallus gallus)
TFAP2A:TFAP2C binds the PAX7 gene (Gallus gallus)
Authored
May, B (2023-05-14)
Reviewed
Patthey, C (2023-10-28)
Gunhaga, L (2023-10-28)
Created
May, B (2023-05-15)
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