Reactome | STAT1,STAT3 binds PKR

STAT1,STAT3 binds PKR

Stable Identifier

R-HSA-9835443

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Unphosphorylated STAT3 shuttles between the nucleus and cytosol. In the cytosol, STAT1 and STAT3 bind to PKR inhibiting its activation and repressing autophagy (Wong et al, 2001; Deb et al, 2001; Shen et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
23084476	Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity Shen, S, Adjemian, S, Malik, SA, Minoux, H, Kepp, O, Kroemer, R, Galluzzi, L, Senovilla, L, Lachkar, S, Pierron, G, Takehara, T, Hikita, H, Mariño, G, Kroemer, G, Maiuri, MC, Souquere, S, Niso-Santano, M	Mol Cell	2012
11278865	Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR Decker, T, Dever, TE, Li, S, Durbin, JE, Wong, AH, Koromilas, AE	J Biol Chem	2001
11350938	Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3 Kadereit, S, Zamanian-Daryoush, M, Deb, A, Williams, BR, Xu, Z	EMBO J	2001