DUS2 binds PKR

Stable Identifier
R-HSA-9835385
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DUS2 binds PKR
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Human tRNA-dihydrouridine synthase-2 (DUS2) binds to protein kinase R (PKR, EIF2AK2) and inhibits its activation. Inhibition of PKR by DUS2 plays an important role in regulating stress-induced apoptosis (Mittelstadt et al, 2007).
Literature References
PubMed ID Title Journal Year
18096616 Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR

Handy, I, Patel, CV, Frump, A, Mittelstadt, M, Patel, RC, Fowlkes, V, Khuu, T

Nucleic Acids Res 2008
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Orthologous Events
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Authored
Stephan, R  (2023-05-13)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-14)
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