Reactome | p-TARBP2 binds PKR

p-TARBP2 binds PKR

Stable Identifier

R-HSA-9835358

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RISC-loading complex subunit TARBP2 (TRBP2) can bind to inactive3 PKR, inhibiting its activation. This effect is enhanced by phosphorylated TARBP2 generated by cellular response to stress, and prevents apoptosis due to sustained PKR activation (Park et al, 1994; Benkirane et al, 1997; Gupta et al, 2003; Daher et al, 2009; Paroo et al, 2010; Clerzius et al, 2011; Sanghvi & Steel, 2011; Chukwurah & Patel, 2018; Ukhueduan et al, 2021).

Literature References

PubMed ID	Title	Journal	Year
19804757	Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling Ye, X, Liu, Q, Chen, S, Paroo, Z	Cell	2009
9034343	Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR Jeang, KT, Gatignol, A, Benkirane, M, Samuel, CE, Smith, SM, Neuveut, C, Chun, RF	EMBO J	1997
21937648	The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR Sanghvi, VR, Steel, LF	J Virol	2011
21294215	Multiple levels of PKR inhibition during HIV-1 replication Clerzius, G, Gélinas, JF, Gatignol, A	Rev Med Virol	2011
34174402	Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation Chukwurah, E, Ukhueduan, B, Patel, RC	Int J Biochem Cell Biol	2021
29348664	Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival Chukwurah, E, Patel, RC	Sci Rep	2018
14585331	The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity Huang, X, Patel, RC, Gupta, V	Virology	2003
7515177	TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR Park, H, Paoletti, E, Davies, MV, Kaufman, RJ, Nam, YS, Langland, JO, Tartaglia, J, Venkatesan, S, Jacobs, BL, Chang, HW	Proc Natl Acad Sci U S A	1994