p-TARBP2 binds PKR

Stable Identifier
Reaction [binding]
Homo sapiens
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RISC-loading complex subunit TARBP2 (TRBP2) can bind to inactive3 PKR, inhibiting its activation. This effect is enhanced by phosphorylated TARBP2 generated by cellular response to stress, and prevents apoptosis due to sustained PKR activation (Park et al, 1994; Benkirane et al, 1997; Gupta et al, 2003; Daher et al, 2009; Paroo et al, 2010; Clerzius et al, 2011; Sanghvi & Steel, 2011; Chukwurah & Patel, 2018; Ukhueduan et al, 2021).
Literature References
PubMed ID Title Journal Year
19804757 Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling

Ye, X, Liu, Q, Chen, S, Paroo, Z

Cell 2009
9034343 Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR

Jeang, KT, Gatignol, A, Benkirane, M, Samuel, CE, Smith, SM, Neuveut, C, Chun, RF

EMBO J 1997
21937648 The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR

Sanghvi, VR, Steel, LF

J Virol 2011
21294215 Multiple levels of PKR inhibition during HIV-1 replication

Clerzius, G, GĂ©linas, JF, Gatignol, A

Rev Med Virol 2011
34174402 Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation

Chukwurah, E, Ukhueduan, B, Patel, RC

Int J Biochem Cell Biol 2021
29348664 Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival

Chukwurah, E, Patel, RC

Sci Rep 2018
14585331 The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity

Huang, X, Patel, RC, Gupta, V

Virology 2003
7515177 TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR

Park, H, Paoletti, E, Davies, MV, Kaufman, RJ, Nam, YS, Langland, JO, Tartaglia, J, Venkatesan, S, Jacobs, BL, Chang, HW

Proc Natl Acad Sci U S A 1994
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