Expression of PAX7 in the neural plate border

Stable Identifier
R-HSA-9835252
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of PAX7 in the neural plate border
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Stimulation of WNT signaling in human embryonic stem cells activates expression of PAX7 via beta-catenin (CTNNB1) early (3 days) in the differentiation process (Leung et al. 2016). The TFAP2A:TFAP2C dimer, SOX2, POU5F1 (OCT4), and MYB bind the PAX7 gene and activate its expression in the neural plate border (inferred from chicken homologs). BMP4 (Leung et al. 2016) and FGF4 (inferred from chicken homologs) also activate PAX7 in the neural plate border.
Literature References
PubMed ID Title Journal Year
26839343 WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate

Prasad, MS, Murdoch, B, Gomez, GA, Salem, AF, García-Castro, MI, Leung, AW

Development 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FGF4 [extracellular region] (Homo sapiens)
Regulator
WNT3A [extracellular region] (Homo sapiens)
Regulator
TFAP2A:TFAP2C:POU5F1:SOX2:MYB:PAX7 gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A:TFAP2C [nucleoplasm]
Regulator
CTNNB1 [nucleoplasm] (Homo sapiens)
Regulator
BMP4 dimer [extracellular region] (Homo sapiens)
Inferred From
Expression of PAX7 in the neural plate border (Gallus gallus)
Authored
May, B  (2023-05-10)
Reviewed
Patthey, C  (2023-10-28)
Gunhaga, L  (2023-10-28)
Created
May, B  (2023-05-12)
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