Reactome | p-PRKRA dimer binds PKR

p-PRKRA dimer binds PKR

Stable Identifier

R-HSA-9834821

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Binding of interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA, PACT) to PKR leads to activation of PKR by dimerization and autophosphorylation. The strength of the
PRKRA-PKR interaction depends on PRKRA dimerization and its stress-induced phosphorylation on serine residues 246 and 287 (Patel & Sen, 1998; Peters et al, 2001; Huang et al, 2002; Peters et al, 2006; Chukwurah et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
11985496	The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR) Huang, X, Hutchins, B, Patel, RC	Biochem J	2002
29231267	Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT Chukwurah, E, Willingham, V, Singh, M, Castillo-Azofeifa, D, Patel, RC	J Cell Biochem	2018
9687506	PACT, a protein activator of the interferon-induced protein kinase, PKR Patel, RC, Sen, GC	EMBO J	1998
11238927	Modular structure of PACT: distinct domains for binding and activating PKR Peters, GA, Hartmann, R, Qin, J, Sen, GC	Mol Cell Biol	2001
16982605	Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis Peters, GA, Li, S, Sen, GC	J Biol Chem	2006