Reactome | ILF3 binds PKR

ILF3 binds PKR

Stable Identifier

R-HSA-9834807

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Upon viral infection, interleukin enhancer-binding factor 3 (also known as NF90, NFAR, DRBP76, MBP4, or ILF3) accumulates in the cytoplasm, where it binds to and activates EIF2AK2 (PKR). Since activated PKR phosphorylates ILF3, resulting in dissociation of ILF3 from its complex with NF45, both processes appear to be part of a feedback loop that enhances PKR signaling (Patel et al, 1999; Parker et al, 2001; Harashima et al, 2010; Wen et al, 2014; Li et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
11438540	Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase Parker, LM, Fierro-Monti, I, Mathews, MB	J Biol Chem	2001
10400669	DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR Patel, RC, Vestal, DJ, Xu, Z, Bandyopadhyay, S, Guo, W, Erme, SM, Williams, BR, Sen, GC	J Biol Chem	1999
27423063	NF90 is a novel influenza A virus NS1-interacting protein that antagonizes the inhibitory role of NS1 on PKR phosphorylation Li, T, Li, X, Zhu, W, Wang, H, Mei, L, Wu, S, Lin, X, Han, X	FEBS Lett	2016
21123651	Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense Harashima, A, Guettouche, T, Barber, GN	Genes Dev	2010
24623135	NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells Wen, X, Huang, X, Mok, BW, Chen, Y, Zheng, M, Lau, SY, Wang, P, Song, W, Jin, DY, Yuen, KY, Chen, H	J Immunol	2014