Synthesis of negative sense genomic RNA of respiratory syncytial virus

Stable Identifier
R-HSA-9834719
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Synthesis of negative sense genomic RNA of respiratory syncytial virus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Replication of antigenomic RNA (+ssRNA) of human respiratory syncytial virus (RSV) A, just like replication of genomic RNA, depends on encapsidation by the protein N, which has regions that interact with both protein P and protein L. Encapsidation protects genomic and antigenomic RNA from degradation as these RNAs do not possess the 5' cap and the poly(A) tail. At least 10-times more progeny genome is produced than antigenome, due to a stronger antigenome promoter and due to the genome being used as a template for both transcription and antigenome synthesis (Fearns et al. 2000; Hanley et al. 2010).
Literature References
PubMed ID Title Journal Year
10846082 Functional analysis of the genomic and antigenomic promoters of human respiratory syncytial virus

Fearns, R, Collins, PL, Peeples, ME

J Virol 2000
20701943 Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation

Hanley, LL, McGivern, DR, Teng, MN, Djang, R, Collins, PL, Fearns, R

Virology 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

RNA-directed RNA polymerase activity of RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol]

Physical Entity
RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol] (Human respiratory syncytial virus A)
Activity
RNA-directed RNA polymerase activity (GO:0003968)
Disease
Cross References
Mondo
Authored
Orlic-Milacic, M  (2023-06-16)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-05-10)
Cite Us!