Synthesis of negative sense genomic RNA of respiratory syncytial virus

Stable Identifier
R-HSA-9834719
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Synthesis of negative sense genomic RNA of respiratory syncytial virus
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Replication of antigenomic RNA (+ssRNA) of human respiratory syncytial virus (RSV) A, just like replication of genomic RNA, depends on encapsidation by the protein N, which has regions that interact with both protein P and protein L. Encapsidation protects genomic and antigenomic RNA from degradation as these RNAs do not possess the 5' cap and the poly(A) tail. At least 10-times more progeny genome is produced than antigenome, due to a stronger antigenome promoter and due to the genome being used as a template for both transcription and antigenome synthesis (Fearns et al. 2000; Hanley et al. 2010).
Literature References
PubMed ID Title Journal Year
10846082 Functional analysis of the genomic and antigenomic promoters of human respiratory syncytial virus

Peeples, ME, Collins, PL, Fearns, R

J Virol 2000
20701943 Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation

Fearns, R, Collins, PL, Teng, MN, Hanley, LL, Djang, R, McGivern, DR

Virology 2010
Participants
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Output
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Catalyst Activity

RNA-dependent RNA polymerase activity of RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol]

Physical Entity
RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol] (Human respiratory syncytial virus A)
Activity
RNA-dependent RNA polymerase activity (GO:0003968)
Disease
Authored
Orlic-Milacic, M  (2023-06-16)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-05-10)
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