Expression of peptide bound class I MHC on cell surface

Stable Identifier
Reaction [omitted]
Homo sapiens
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After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.

Literature References
PubMed ID Title Journal Year
20605430 Passage through the Golgi

Luini, A, Nakano, A

Curr Opin Cell Biol 2010
19193869 Mechanisms of transport through the Golgi complex

Jackson, CL

J Cell Sci 2009
11163199 Selective export of MHC class I molecules from the ER after their dissociation from TAP

Manley, H, Spiliotis, ET, Edidin, M, Zúñiga, MC, Osorio, M

Immunity 2000
Orthologous Events
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