Reactome | Disassembly of COPII coated vesicle

Disassembly of COPII coated vesicle

Stable Identifier

R-HSA-983422

Type

Reaction [transition]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane, cytosol

ReviewStatus

5/5

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Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.

Literature References

PubMed ID	Title	Journal	Year
10825291	COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP	J Cell Sci	2000
10982397	Dynamics of transitional endoplasmic reticulum sites in vertebrate cells Hammond, AT, Glick, BS	Mol Biol Cell	2000
17316621	Mechanisms of COPII vesicle formation and protein sorting Sato, K, Nakano, A	FEBS Lett	2007