Disassembly of COPII coated vesicle

Stable Identifier
R-HSA-983422
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.

Literature References
PubMed ID Title Journal Year
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Glick, BS, Hammond, AT

Mol Biol Cell 2000
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R

J Cell Sci 2000
17316621 Mechanisms of COPII vesicle formation and protein sorting

Nakano, A, Sato, K

FEBS Lett 2007
Participants
Participates
Catalyst Activity

GTPase activity of COPII [ER to Golgi transport vesicle membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!