NS1 (1C) binds to CREBBP

Stable Identifier
R-HSA-9833446
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
nucleoplasm
ReviewStatus
5/5
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NS1 (1C) binds to CREBBP
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After hRSV nonstructural protein 1C (NS1) localizes to the nucleus, it binds to both phosphorylated IRF3 dimer and CREB-binding protein (CREBBP), preventing association of these two proteins and the subsequent stimulation of expression of interferon-beta (Ren et al, 2011).
Literature References
PubMed ID Title Journal Year
21632562 A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein

Ren, J, Bao, X, Casola, A, Li, K, Liu, T, Garofalo, RP, Pang, L

J Gen Virol 2011
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as an event of
Disease
Authored
Stephan, R  (2023-04-25)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-04-26)
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