N interacts with IFIH1

Stable Identifier
R-HSA-9833393
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
Synonyms
N interacts with MDA5
ReviewStatus
5/5
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N interacts with IFIH1
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hRSV nucleoprotein N, localized in viral inclusion bodies near the host cell plasma membrane, binds MDA5 (IFIH1), downregulating the interferon response activated by the MAVS:IFIH1 complex assembly (Lifland et al, 2012).
Literature References
PubMed ID Title Journal Year
22623778 Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS

Zurla, C, Crowe, JE, Alonas, E, Lifland, AW, Santangelo, PJ, Jung, J

J Virol 2012
Participants
Input
Output
Participates
as an event of
Disease
Authored
Stephan, R  (2023-04-23)
Reviewed
Bergeron, HC  (2023-11-10)
Created
Stephan, R  (2023-04-23)
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