MAVS and DDX58 interact

Stable Identifier
R-HSA-9833388
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol, mitochondrial outer membrane, mitochondrial matrix
ReviewStatus
5/5
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MAVS and DDX58 interact
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Mitochondrial antiviral signaling protein (MAVS, IPS-1) acts as an adaptor linking RIG-I (also known as retinoic acid-inducible gene I protein RIG-1 or DExD/H-box helicase 58, DDX58) and MDA5 (IFIH1) to downstream molecules that activate TBK1 and IKKi (Kawai et al, 2005; Seth et al, 2005).
Literature References
PubMed ID Title Journal Year
16125763 Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

Seth, RB, Chen, ZJ, Sun, L, Ea, CK

Cell 2005
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Takeuchi, O, Ishii, KJ, Kumar, H, Sato, S, Kawai, T, Takahashi, K, Kato, H, Coban, C

Nat Immunol 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TRIM25:NS1 [cytosol] (Homo sapiens)
Regulator
NS1:MAVS [mitochondrial outer membrane] (Homo sapiens)
Regulator
DDX58:NS2 [cytosol] (Homo sapiens)
Authored
Stephan, R  (2023-04-15)
Reviewed
Bergeron, HC  (2023-11-10)
Created
Stephan, R  (2023-04-22)
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