Expression of WNT9B during nephron development

Stable Identifier
R-HSA-9833362
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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HNF1B binds and activates expression of the WNT9B gene in the ureteric bud (inferred from mouse homologs). In mouse embryos homozygous null for Hnf1b, expression of Wnt9b is completely lost in the nephric duct and the ureteric bud (Lokmane et al. 2010). The homozygous Hnf1b mutants have severely reduced renal development, defective ureteric branching, and few metanephric mesenchyme condensations (Lokmane et al. 2010).
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