Ubiquitination of STAT2

Stable Identifier
R-HSA-9833155
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Ubiquitination of STAT2
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Human signal transducer and activator of transcription 2 (STAT2) is subject to ubiquitination by, among other E3 ubiquitin ligases, a complex consisting of human respiratory syncytial virus (hRSV) protein NS1 with elongin C (ELOC) and cullin-5 (CUL5). This leads to loss of STAT2 protein in RSV-infected cells, which downregulates the host type I interferon response (Elliott et al, 2007).
Literature References
PubMed ID Title Journal Year
17251292 Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

Power, UF, Johnston, JA, Touzelet, O, Stevenson, NJ, Elliott, J, Boyd, CR, Buick, R, Lynch, OT, Suessmuth, Y, Burrows, JF, Qian, P, Gadina, M

J Virol 2007
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Catalyst Activity

ubiquitin-protein transferase activity of NS1:Cul5-SCF [cytosol]

Physical Entity
NS1:Cul5-SCF [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Disease
Authored
Stephan, R  (2023-06-14)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-04-13)
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