Ubiquitination of STAT2

Stable Identifier
R-HSA-9833155
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ubiquitination of STAT2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Human signal transducer and activator of transcription 2 (STAT2) is subject to ubiquitination by, among other E3 ubiquitin ligases, a complex consisting of human respiratory syncytial virus (hRSV) protein NS1 with elongin C (ELOC) and cullin-5 (CUL5). This leads to loss of STAT2 protein in RSV-infected cells, which downregulates the host type I interferon response (Elliott et al, 2007).
Literature References
PubMed ID Title Journal Year
17251292 Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

Elliott, J, Lynch, OT, Suessmuth, Y, Qian, P, Boyd, CR, Burrows, JF, Buick, R, Stevenson, NJ, Touzelet, O, Gadina, M, Power, UF, Johnston, JA

J Virol 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of NS1:Cul5-SCF [cytosol]

Physical Entity
NS1:Cul5-SCF [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Disease
Cross References
Mondo
Authored
Stephan, R  (2023-06-14)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-04-13)
Cite Us!