Association of NS1 (1C) with Cul5 and SCF

Stable Identifier
R-HSA-9833107
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Association of NS1 (1C) with Cul5 and SCF
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hRSV nonstructural protein 1C (NS1) binds to the elongin C (ELOC) and cullin-5 (CUL5) components of the Cul5-SCF complex to direct the ubiquitination and proteasome-dependent degradation of STAT2 (Elliott et al, 2007).
Literature References
PubMed ID Title Journal Year
17251292 Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

Elliott, J, Lynch, OT, Suessmuth, Y, Qian, P, Boyd, CR, Burrows, JF, Buick, R, Stevenson, NJ, Touzelet, O, Gadina, M, Power, UF, Johnston, JA

J Virol 2007
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Cross References
Mondo
Authored
Stephan, R  (2023-04-10)
Reviewed
Bergeron, HC  (2023-11-15)
Created
Stephan, R  (2023-04-13)
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