Expression of GBX2 in posterior neural plate

Stable Identifier
R-HSA-9833063
Type
Reaction [uncertain]
Species
Homo sapiens
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ReviewStatus
5/5
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Expression of GBX2 in the posterior neural plate is strongly enhanced by SOX2, though it is unclear if SOX2 directly binds the GBX2 gene (inferred from mouse homologs). ZEB2 (SIP1) increases expression of GBX2 in human embryonic stem cells overexpressing ZEB2 and this effect is inferred to also occur in the neural plate (Chng et al. 2010). OTX2 produced in the anterior neural plate is able to repress expression of GBX2 even in the presence of SOX2 (inferred from mouse homologs). The mutual antagonism of GBX2 and OTX2 appears to regulate midbrain and hindbrain patterning (inferred from mouse embryos).
Literature References
PubMed ID Title Journal Year
20074535 SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells

Pedersen, RA, Chng, Z, Vallier, L, Teo, A

Cell Stem Cell 2010
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