Expression of OTX2 in anterior neural plate

Stable Identifier
R-HSA-9832938
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of OTX2 in anterior neural plate
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OTX2 is expressed specifically in the anterior neural plate but not in the posterior neural plate (inferred from mouse embryos). POU3F1 binds the OTX2 gene and activates expression (inferred from mouse embryonic stem cells). GBX2 from the posterior neural plate represses expression by directly binding the OTX2 gene (inferred from mouse homologs).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GBX2:OTX2 gene [nucleoplasm] (Homo sapiens)
Active Unit
GBX2 [nucleoplasm]
Positively by
Regulator
POU3F1:OTX2 gene [nucleoplasm] (Homo sapiens)
Active Unit
POU3F1 [nucleoplasm]
Inferred From
Expression of Otx2 in anterior neural plate (Mus musculus)
Authored
May, B  (2023-04-10)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-10)
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