Reactome | KLC1 [cytosol]

KLC1 [cytosol]

Stable Identifier

R-HSA-983284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kinesin light chain 1, KLC1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07866 KLC1

Gene Names

KLC1, KLC, KNS2

Chain

chain:1-573

Reference Genes

BioGPS Gene:3831 KLC1

COSMIC (genes):KLC1 KLC1

CTD Gene:3831 KLC1

dbSNP Gene:3831 KLC1

ENSEMBL:ENSG00000126214.22 KLC1

HGNC:6387 KLC1

KEGG Gene (Homo sapiens):3831 KLC1

Monarch:3831 KLC1

NCBI Gene:3831 KLC1

OMIM:600025 KLC1

UCSC:Q07866 KLC1

Reference Transcript

Other Identifiers

11725812_a_at

11743814_a_at

11748161_at

11750129_x_at

11760858_a_at

16789258

16789305

212877_PM_at

212877_at

212878_PM_s_at

212878_s_at

213656_PM_s_at

213656_s_at

232036_PM_at

232036_at

239793_PM_at

239793_at

3553773

3553774

3553875

3553876

3553878

3553881

3553882

3553883

3553884

3553885

3553886

3553887

3553888

3553889

3553890

3553892

3553894

3553899

3553900

3553901

3553902

3553903

3553904

3553906

3553908

3553910

3553911

3553913

3553914

3553915

3553924

3553945

3553946

3553948

3553949

3553950

3553951

3553952

3553953

3553972

3553974

3831

39057_at

59677_at

64835_r_at

76274_at

7977127

81201_at

A_14_P101374

A_14_P106466

A_14_P133764

A_23_P2873

A_24_P922877

A_24_P932760

GE57558

GO:0003774

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0007018

GO:0008092

GO:0016020

GO:0019894

GO:0030426

GO:0031410

GO:0035617

GO:0042995

GO:0043226

HMNXSV003012915

HMNXSV003044426

Hs.117977.1.A1_3p_a_at

Hs.120827.0.A1_3p_at

Hs.156067.0.S1_3p_at

Hs.274440.0.S1_3p_s_at

ILMN_1654653

ILMN_1726901

L04733_at

PH_hs_0026749

PH_hs_0035378

TC14000806.hg

TC14002312.hg

p5029

p5032

Participates

as a member of

KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)

Other forms of this molecule

KLC1(1-420)-p-7Y ALK(1058-1620) fusion [cytosol]

KLC1(1-420)-ALK(1058-1620) fusion [cytosol]

Inferred To

klc-2 [cytosol] (Caenorhabditis elegans)

KLC1 [cytosol] (Bos taurus)

KLC1 [cytosol] (Canis familiaris)

KLC1 [cytosol] (Danio rerio)

KLC1 [cytosol] (Gallus gallus)

KLC1 [cytosol] (Sus scrofa)

Klc [cytosol] (Drosophila melanogaster)

Klc1 [cytosol] (Mus musculus)

Klc1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_005543.2, NP_891553.2, NP_001123579.1

OpenTargets

ENSG00000126214

GeneCards

Q07866

HPA

ENSG00000126214-KLC1

Ensembl

ENST00000557450, ENSG00000126214, ENSP00000334618, ENST00000348520, ENSP00000374394, ENSP00000488938, ENST00000389744, ENSP00000450648, ENSP00000450616, ENST00000246489, ENST00000634686, ENST00000554228, ENSP00000452487, ENSP00000414982, ENST00000553286, ENSP00000341154, ENST00000334553, ENSP00000334523, ENST00000452929, ENST00000347839, ENSP00000246489

PRO

Q07866

Pharos - Targets

Q07866

PDB

7AIE, 3NF1, 5OJ8, 7AI4

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.601	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3