Reactome | RAD51B [nucleoplasm]

RAD51B [nucleoplasm]

Stable Identifier

R-HSA-983271

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD51 homolog 2, RAD51L1, RA51B_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex binds D-loop structures (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex formation (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        BLM mediates dissolution of double Holliday junction (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        FIGNL1 binds RAD51 (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
        
        D-loop dissociation and strand annealing (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15315 RAD51B

Gene Names

RAD51B, RAD51L1, REC2

Chain

chain:1-384

Reference Genes

BioGPS Gene:5890 RAD51B

COSMIC (genes):RAD51B RAD51B

CTD Gene:5890 RAD51B

dbSNP Gene:5890 RAD51B

ENSEMBL:ENSG00000182185 RAD51B

ENSEMBL_homo_sapiens_GENE:ENSG00000182185.19 RAD51B

HGNC:9822 RAD51B

KEGG Gene (Homo sapiens):5890 RAD51B

Monarch:5890 RAD51B

NCBI Gene:5890 RAD51B

OMIM:602948 RAD51B

UCSC:O15315 RAD51B

Reference Transcript

Other Identifiers

11736967_at

11737562_a_at

1554496_PM_at

1554496_at

216880_PM_at

216880_at

3541499

3541505

3541506

3541507

3541508

3541509

3541515

3541516

3541519

3541521

3541522

3541560

3541583

3541595

3541609

3541610

3541617

3541618

3541625

3541628

3541714

5890

67167_at

7975292

A_14_P102997

A_14_P116967

A_32_P517715

GE59568

GO:0000166

GO:0000278

GO:0000400

GO:0000724

GO:0001701

GO:0001832

GO:0003677

GO:0003690

GO:0003697

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0006259

GO:0006281

GO:0006310

GO:0006974

GO:0007131

GO:0008094

GO:0008284

GO:0010971

GO:0016787

GO:0016887

GO:0022414

GO:0033063

GO:0043226

GO:0048856

GO:0061053

GO:0140013

GO:0140097

GO:0140299

GO:0140657

GO:0140664

Hs.100669.1.A1_3p_at

Hs.100669.1.A1_3p_x_at

Hs2.100669.3.A1_3p_at

ILMN_1801262

ILMN_1802392

PH_hs_0026593

Participates

as a component of

as an input of

Inferred To

RAD51B [nucleoplasm] (Bos taurus)

RAD51B [nucleoplasm] (Canis familiaris)

RAD51B [nucleoplasm] (Gallus gallus)

RAD51B [nucleoplasm] (Mus musculus)

RAD51B [nucleoplasm] (Sus scrofa)

rad51b [nucleoplasm] (Danio rerio)

Rad51b [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002868.1, NP_001308746.1, NP_598193.2, NP_598194.1

OpenTargets

ENSG00000182185

HPA

ENSG00000182185-RAD51B

GeneCards

O15315

Ensembl

ENST00000471583, ENSG00000182185, ENSP00000418859, ENSP00000420061, ENSP00000419471, ENST00000487270, ENST00000488612

PRO

O15315

Pharos - Targets

O15315

Orphanet

24847

PDB

8GBJ, 8OUZ, 8OUY, 8FAZ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43502 RAD51C	1	RAD51C [nucleoplasm] (R-HSA-217039)	0.94	16
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.81	8
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.641	5
UniProt:P07305 H1-0	1	H1F0 [nucleoplasm] (R-HSA-206132)	0.558	2
UniProt:Q86UA6 RIP			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q6NVH7 SWAP1			0.524	2

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