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WT1 binds the PAX2 gene
Stable Identifier
R-HSA-9832334
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Nephron development (Homo sapiens)
WT1 binds the PAX2 gene (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
WT1 binds sites in the 5' untranslated region of the PAX2 gene and represses transcription (inferred from mouse homologs). In mouse embryos, repression of Pax2 by Wt1 is involved in podocyte specification in the proximal region of renal vesicles and later stages (Kreidberg et al. 1993).
Participants
Input
PAX2 gene [nucleoplasm]
(Homo sapiens)
WT1 [nucleoplasm]
(Homo sapiens)
Output
WT1:PAX2 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Nephron development (Homo sapiens)
Inferred From
Wt1 binds the Pax2 gene (Mus musculus)
Authored
May, B (2023-03-29)
Created
May, B (2023-03-30)
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