LFNG, a component glycosyltransferase of the NOTCH signaling pathway, is initially expressed at a low level in the distal region of renal vesicles (inferred from mouse embryos in Heliot et al. 2013). In subsequent comma-shaped bodies and S-shaped bodies, HNF1B binds the promoter of the LFNG gene and enhances expression (inferred from mouse homologs in Heliot et al. 2013). LFNG is expressed in the distal region of comma-shaped bodies and in the proximal region of S-shaped bodies, where it appears to play a role in the proximo-distal differentiation of nephrons (inferred from mouse embryos in Heliot et al. 2013).