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Expression of JAG1 during nephron development
Stable Identifier
R-HSA-9832187
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
plasma membrane
ReviewStatus
3/5
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Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Nephron development (Homo sapiens)
Expression of JAG1 during nephron development (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
JAG1, a ligand for NOTCH receptors, is expressed in tubules of the metanephric kidney (Crosnier et al. 2000 and inferred from mouse embryos). JAG1 is initially expressed in the distal region of renal vesicles, then HNF1B, possibly acting via DLL1 and NOTCH signaling, maintains JAG1 expression in the distal region of comma-shaped bodies and in the proximal region of S-shaped bodies (inferred from mouse homologs and embryos in Heliot et al. 2013).
Participants
Input
JAG1 gene [nucleoplasm]
(Homo sapiens)
Output
JAG1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Nephron development (Homo sapiens)
This event is regulated
Positively by
Regulator
HNF1B [nucleoplasm]
(Homo sapiens)
Inferred From
Expression of Jag1 during nephron development (Mus musculus)
Authored
May, B (2023-03-28)
Created
May, B (2023-03-29)
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