Expression of JAG1 during nephron development

Stable Identifier
R-HSA-9832187
Type
Reaction [omitted]
Species
Homo sapiens
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ReviewStatus
3/5
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JAG1, a ligand for NOTCH receptors, is expressed in tubules of the metanephric kidney (Crosnier et al. 2000 and inferred from mouse embryos). JAG1 is initially expressed in the distal region of renal vesicles, then HNF1B, possibly acting via DLL1 and NOTCH signaling, maintains JAG1 expression in the distal region of comma-shaped bodies and in the proximal region of S-shaped bodies (inferred from mouse homologs and embryos in Heliot et al. 2013).
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