Kinesin-1 is a heterotetramer of two heavy chains (HCs) and two light chains (LCs). The HC tail binds microtubules and inhibits ATPase activity by interacting with the enzymatic HC heads. LCs regulate the head and microtubule-binding activities of the HC tail by reducing the affinity of the head-tail interaction over tenfold. By a separate mechanism LCs inhibit microtubule binding.
Vaisberg, EA, Chernyak, VY, Kuznetsov, SA, Magretova, NN, Shanina, NA, Gelfand, VI
Brady, ST, Pfister, KK, Wagner, MC, Bloom, GS
Vale, RD, McCaffrey, G, Navone, F, Niclas, J, Sparks, L, Hom-Booher, N, Bernstein, HD
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