Reactome | Kinesin-1 is a heterotetramer

Kinesin-1 is a heterotetramer

Stable Identifier

R-HSA-983194

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Kinesin-1 is a heterotetramer of two heavy chains (HCs) and two light chains (LCs). The HC tail binds microtubules and inhibits ATPase activity by interacting with the enzymatic HC heads. LCs regulate the head and microtubule-binding activities of the HC tail by reducing the affinity of the head-tail interaction over tenfold. By a separate mechanism LCs inhibit microtubule binding.

Literature References

PubMed ID	Title	Journal	Year
3134048	Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide Bloom, GS, Wagner, MC, Pfister, KK, Brady, ST	Biochemistry	1988
3130248	The quaternary structure of bovine brain kinesin Kuznetsov, SA, Vaisberg, EA, Shanina, NA, Magretova, NN, Chernyak, VY, Gelfand, VI	EMBO J	1988
1607388	Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells Navone, F, Niclas, J, Hom-Booher, N, Sparks, L, Bernstein, HD, McCaffrey, G, Vale, RD	J Cell Biol	1992