Reactome | Class I MHC mediated antigen processing & presentation

Class I MHC mediated antigen processing & presentation

Stable Identifier

R-HSA-983169

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Class I MHC mediated antigen processing & presentation

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Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface.

Literature References

PubMed ID	Title	Journal	Year
17055423	The complex route to MHC class I-peptide complexes Elliott, T, Neefjes, J	Cell	2006
18243674	Molecular machinations of the MHC-I peptide loading complex Purcell, AW, Elliott, T	Curr Opin Immunol	2008
12495737	Assembly and export of MHC class I peptide ligands Antoniou, AN, Powis, SJ, Elliott, T	Curr Opin Immunol	2003
18641646	The known unknowns of antigen processing and presentation Vyas, JM, Van der Veen, AG, Ploegh, HL	Nat Rev Immunol	2008
8717519	Antigen processing and presentation by the class I major histocompatibility complex York, IA, Rock, KL	Annu Rev Immunol	1996
17145306	Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions Loureiro, J, Ploegh, HL	Adv Immunol	2006
18926908	The quality control of MHC class I peptide loading Wearsch, PA, Cresswell, P	Curr Opin Cell Biol	2008